May administer additional amounts as clinically indicated. Preoperative dilution of blood using albumin and crystalloids can be used. May repeat dose every 4 to 12 hours as needed. Use when normal saline infusion fails to achieve or maintain hemodynamic stability and urine output. Requirements in patients with pre-existing hypoproteinemia or hepatic impairment may be greater. Individualize dosage based on careful monitoring of clinical parameters in all patient populations.
Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed.
Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.
Albumin is a transparent or slightly opalescent solution which may have a greenish tint or may vary from pale straw to amber color. Albumin may be given undiluted. Acceptable diluents include 0. Do not mix or add with other medicinal products including blood and blood components, protein hydrolysates, or solutions containing alcohol. Do not add supplementary medication.
Storage: Administer within 4 hours of entering the container. More rapid administration can cause circulatory overload and pulmonary edema. Generic: - Store below 86 degrees F Albuked : - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion. Do not store for later use. Albumarc: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion.
Albuminar: - Discard product if it contains particulate matter, is cloudy, or discolored - Store between 68 to 77 degrees F, excursions permitted 59 to 86 degrees F Albuminex: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Do not freeze - Protect from light - Store in carton AlbuRx : - Discard product if it contains particulate matter, is cloudy, or discolored - Store at room temperature not exceeding 86 degrees F Albutein: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion.
Buminate: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion. Flexbumin: - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion. Macrotec: - Refrigerate between 36 and 46 degrees F Plasbumin: - Avoid temperatures above 86 degrees F - Discard product if it contains particulate matter, is cloudy, or discolored - Discard unused portion.
Use of albumin is contraindicated in patients with a history of albumin hypersensitivity or hypersensitivity to any of the excipients. Discontinue administration immediately and institute appropriate medical treatment if a hypersensitivity reaction is suspected. Albumin is contraindicated in patients with severe anemia or heart failure with normal or increased intravascular volume. Monitor coagulation and hematology parameters when large volumes are replaced. Ensure adequate substitution of other blood constituents e.
Monitor electrolyte status and take appropriate steps to address electrolyte imbalance. Discontinue albumin administration at the first sign of cardiovascular overload e. Albumin increases plasma volume and can cause vascular overload, especially after rapid infusion. Monitor blood pressure in trauma and postoperative surgery patients in order to detect rebleeding secondary to clot disruption. Closely monitor hemodynamic parameters for evidence of increased intracranial pressure and cardiac, respiratory, or renal failure in all patients.
Accumulation at concentrations associated with central nervous system and bone toxicity is more likely to occur in patients with renal disease or in premature neonates with immature kidneys. Albumin is a derivative of human blood. As with other products derived from or purified with human blood components, the remote possibility of contamination with Creutzfeldt-Jakob disease CJD or other viral infections exists in patients receiving albumin.
The manufacturing processes are designed to reduce the risk of transmitting viral infection. No cases of transmission of viral illness or CJD have ever been identified for albumin. Report all infections thought to have been transmitted by albumin to the manufacturer.
Patients with marked dehydration require the administration of additional fluids when treated with concentrated albumin. Monitor patients carefully to guard against circulatory overload and hyperhydration. To provide you with the most relevant and helpful information and to understand which information is beneficial, we may combine your e-mail and website usage information with other information we have about you.
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